Research Summary
Current research activities are focused in three distinct areas: artificial organs, bioseparations and membrane processes with the goal is of developing a more fundamental understanding of the factors governing the behavior of these processes, including t
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Research Keywords
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Projects
Recent Publications
Impact of proteins and protein fouling on virus retention during virus removal filtration
Afzal, M. A. & Zydney, A. L., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 710-718 9 p.Research output: Contribution to journal › Article › peer-review
Tangential flow filtration for continuous processing of crystallized proteins
Behboudi, A., Minervini, M., Kedzierski, A., Azzariti, L. & Zydney, A. L., May 25 2024, In: Separation and Purification Technology. 336, 126311.Research output: Contribution to journal › Article › peer-review
Filtration of a multi-serotype glycoconjugate vaccine drug product through sterilizing grade 0.2/0.22 µm pore size filters
Du, Z., Qiu, S., Gill, K., Toprani, V. & Zydney, A. L., Feb 2024, In: Biotechnology Journal. 19, 2, 2300450.Research output: Contribution to journal › Article › peer-review
Membrane technology for the purification of RNA and DNA therapeutics
Javidanbardan, A., Messerian, K. O. & Zydney, A. L., 2024, (Accepted/In press) In: Trends in Biotechnology.Research output: Contribution to journal › Review article › peer-review
Optimizing particle morphology during antibody precipitation for enhanced tangential flow filtration performance
Minervini, M., Behboudi, A., Marzella, J. R. & Zydney, A. L., Jun 19 2024, In: Separation and Purification Technology. 338, 126574.Research output: Contribution to journal › Article › peer-review
Effect of density variations and buoyancy on flow in small-scale depth filter capsules
Naghashnejad, M., Ghajar, G., Fernandez-Cerezo, L., Roush, D. J., Borhan, A. & Zydney, A. L., May 2024, In: Journal of Membrane Science. 702, 122749.Research output: Contribution to journal › Article › peer-review
Co-current filtrate flow in TFF perfusion processes: Decoupling transmembrane pressure from crossflow to improve product sieving
Romann, P., Giller, P., Sibilia, A., Herwig, C., Zydney, A. L., Perilleux, A., Souquet, J., Bielser, J. M. & Villiger, T. K., Feb 2024, In: Biotechnology and bioengineering. 121, 2, p. 640-654 15 p.Research output: Contribution to journal › Article › peer-review
Proteomic analysis of host cell protein fouling during bioreactor harvesting
Zhang, D., Wickramasinghe, S. R., Zydney, A. L., Smelko, J. P., Loman, A., Wheeler, A. & Qian, X., 2024, (Accepted/In press) In: Biotechnology progress.Research output: Contribution to journal › Article › peer-review
The role of intermolecular interactions on monoclonal antibody filtration through virus removal membranes
Billups, M., Minervini, M., Holstein, M., Feroz, H., Ranjan, S., Hung, J. & Zydney, A. L., Dec 2023, In: Biotechnology Journal. 18, 12, 2300265.Research output: Contribution to journal › Article › peer-review
Data-science-based reconstruction of 3-D membrane pore structure using a single 2-D micrograph
Chamani, H., Rabbani, A., Russell, K. P., Zydney, A. L., Gomez, E. D., Hattrick-Simpers, J. & Werber, J. R., Jul 15 2023, In: Journal of Membrane Science. 678, 121673.Research output: Contribution to journal › Article › peer-review
Single-Pass Tangential Flow Filtration (SPTFF) of Nanoparticles: Achieving Sustainable Operation with Dilute Colloidal Suspensions for Gene Therapy Applications
Chaubal, A. S. & Zydney, A. L., Apr 2023, In: Membranes. 13, 4, 433.Research output: Contribution to journal › Article › peer-review
Comparison of host cell protein removal by depth filters with diatomaceous earth and synthetic silica filter aids using model proteins
Chu, L. K., Borujeni, E. E., Xu, X., Ghose, S. & Zydney, A. L., Jul 2023, In: Biotechnology and bioengineering. 120, 7, p. 1882-1890 9 p.Research output: Contribution to journal › Article › peer-review
Sterile filtration of a multi-serotype glycoconjugate vaccine drug product
Du, Z., Gill, K., Toprani, V. & Zydney, A. L., May 2023, In: Biotechnology and bioengineering. 120, 5, p. 1316-1322 7 p.Research output: Contribution to journal › Article › peer-review
Smart Manufacturing Implementation of a Continuous Downstream Precipitation and Filtration Process for Antibody Purification
Ghosh, S., Mergy, M., Minervini, M., Okpanum, J., Cramer, S. M., Bequette, B. W., Zydney, A. L. & Przybycien, T. M., Oct 6 2023, In: Smart and Sustainable Manufacturing Systems. 7, 1, p. 129-147 19 p.Research output: Contribution to journal › Article › peer-review
Characterization and associated pressure-dependent behavior of deposits formed during sterile filtration of mRNA-Lipid nanoparticles
Messerian, K. O., Zverev, A., Kramarczyk, J. F. & Zydney, A. L., Oct 15 2023, In: Journal of Membrane Science. 684, 121896.Research output: Contribution to journal › Article › peer-review